Ph.D. in Chemistry, New York University.
Advisor: Dr. Nadrian C. Seeman.
Thesis: Construction and
Application of Single-Stranded Nucleic Acid Knots
B.A. in Chemistry, New York University.
Research Associate at Harvard University, 1999-Present
Research Associate at The Scripps Research Institute, 1997-1999.
Research Associate at New York University, 1996-1997.
Graduate Research Fellow at New York University 1992-1996.
Graduate Teaching Fellow at New York University 1990-1992.
Research Papers
X.J. Li, H. Wang & N.C. Seeman. "Direct Evidence for
Holliday Junction
Crossover Isomerization." Biochemistry. 36, 4240-4247 (1997).
F. Liu, H.Wang & N.C. Seeman. "Short Extensions to
Sticky Ends for DNA
Nanotechnology and DNA-based Computation" Nanobiology, 4,
257-262 (1997).
H. Wang, R.J. Di Gate & N.C. Seeman. "An RNA Topoisomerase."
Proceedings of the National Academy of Sciences, USA. 93, 9477-9482
(1996).
H. Wang & N.C. Seeman. "Structural Domains of DNA
Mesojunctions."
Biochemistry. 34, 920-929 (1995).
S.M. Du, H. Wang, Y-C. Tse-Dinh & N.C. Seeman. "Topological
Transformations of Synthetic DNA Knots." Biochemistry. 34,
673-682
(1995).
H. Wang, S.M. Du & N.C. Seeman. "Tight Single-Stranded
DNA Knots."
Journal of Biomolecular Structure & Dynamics. 10, 853-863
(1993).
Reviews
N.C. Seeman, H. Wang, X. Yang, F. Liu, C. Mao, W. Sun, L. Wenzler, Z.
Shen, R. Sha, H. Yan, M.H. Wong, P. Sa-Ardyen, B. Liu, H. Qiu, X. Li, J.
Qi, S.M. Du, Y. Zhang, J.E. Mueller, T.-J. Fu, Y. Wang, and J. Chen, "New
Motifs in DNA Nanotechnology", Nanotechnology 9, 257-273 (1998).
N.C. Seeman, J. Chen, S.M. Du, J.E. Mueller, Y. Zhang, T.-Ju
Fu, Y.
Wang, H.Wang & S. Zhang. "Synthetic DNA Knots and Catenanes."
New
Journal of Chemistry. 17, 793-755 (1993).
Proceedings/Book Chapters
H. Wang, R.J. Di Gate and N.C. Seeman, E. coli DNA "The
Construction of
an RNA Knot and its Role in Demonstrating that Topoisomerase III
is an RNA
Topoisomerase." Structure, Motion, Interaction and Expression
of
Biological Macromolecules, ed by R.H. Sarma and M.H. Sarma, Adenine
Press,
New York, pp. 103-116 (1998).
N.C. Seeman, J. Chen, Y. Zhang, B. Liu, H. Qiu, T.-J. Fu, Y.
Wang, X.
Li, X. Yang, J. Qi, F. Liu, L.A. Wenzler, S, Du, J.E. Mueller,
H. Wang, C.
Mao, W. Sun, Z. Shen, M.H. Wong, H, Yan and R. Sha, "A Bottom-Up
Approach
to Nanotechnology Using DNA", In: Biological Molecules in
Nanotechnology,
ed. by S.C. Lee, IBC Libraries, Southborough, MA, Chapter 8 (1998).
N.C. Seeman, H. Wang, B. Liu, J. Qi, X. Li, X. Yang, F. Liu,
W. Sun, Z.
Shen, Y. Wang, R. Sha, C. Mao, S. Zhang, T.-J. Fu, S. M. Du, J.E.
Mueller,
Y. Zhang and J. Chen, "The Perils of Polynucleotides: The
Experimental Gap
Between the Design and Assembly of Unusual DNA Structures",
In: DNA Based
Computers II, ed.by L.F. Landweber and E.B. Baum, Am. Math. Soc.,
Providence, pp. 215-233 (1998).
N.C. Seeman, H. Wang, J. Qi., X.J. Li, X.P. Yang, Y. Wang,
H. Qiu, B.
Liu, Z. Shen, W. Sun, F. Liu, J.J. Molenda, S.M. Du, J. Chen,
J.E.
Mueller., Y.Zhang, T.-J. Fu, and S. Zhang, "DNA Nanotechnology
and Topology". In:
Biological Structure and Dyinamics, ed. by R.H. Sarma and M.H.
Sarma,
Adenine Press, New York, vol. 2, pp. 319-341 (1996)
N.C. Seeman, Y. Zhang, S.M. Du, H. Wang, J.E. Mueller, Y. Wang,
B. Liu,
J.Qi and J. Chen, "The Control of DNA Structure and Topology:
An Overview".
Molecularly Designed Ultrafine/Nanostructured Materials: Materials
Research Society Symposium Proceedings 351 57-66 (1994).
Abstracts
H. Wang, R.J. Di Gate & N.C. Seeman. "E. coli DNA
Topoisomerase III is
an RNA Topoisomerase." Tenth Conversation: Biomolecular Stereodynamics,
June 1997. Albany, New York.
H. Wang, R.J. Di Gate & N.C. Seeman. "An RNA Topoisomerase."
41st
Annual Meeting of the Biophysical Society, March 1997, New Orleans,
Louisiana.
H. Wang & N.C. Seeman. "Structural Domains of DNA
Mesojunctions."
Ninth Conversation: Biomolecular Stereodynamics, June 1995. Albany,
New
York. Abstract # a253.
H. Wang, S.M. Du & N.C. Seeman. "Tight Single-Stranded
DNA Knots."
Eighth Conversation: Biomolecular Stereodynamics, June 1993. Albany,
New
York. Abstract # a174.
Oral Presentation
"An RNA Topoisomerase." Tenth Conversation: Biomolecular
Stereodynamics,
June 1997. Albany, New York.