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O'Shea Lab > Publications

F.H. Lam, D.J. Steger, & E.K. O'Shea, Chromatin Decouples Promoter Threshold from Dynamic Range, Nature, 453, 246-250 (2008). Harvard Users External Users.

Y.-S. Lee, K. Huang, F.A. Quiocho & E.K. O'Shea, Molecular Basis of Cyclin-CDK-CKI Regulation by Reversible Binding of an Inositol Pyrophosphate, Nature Chemical Biology, 4(1), 25-32 (2008). Harvard Users External Users.

K. Huang, I. Ferrin-O'Connell, W. Zhang, G. Leonard, E.K. O'Shea & F. A. Quiocho, Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway, Molecular Cell, 28(4):614-23 (2007).pdf

M.J. Rust, J.S. Markson, W.S. Lane, D.S. Fisher & E.K. O'Shea, Ordered Phosphorylation Governs Oscillation of a Three-Protein Circadian Clock, Science, 318, 809-812 (2007). Abstract Pub Med

D.Wykoff, A. Rizvi, J. Raser, B. Margolin and E. K. O'Shea, Positive feedback regulates switching of phosphate transporters in S. cerevisiae, Molecular Cell 27, 1005-1013 (2007). pdf

Y-S. Lee, S. Mulugu, J. D. York, and E. K. O’Shea, Regulation of a Cyclin/CDK/CDK Inhibitor Complex by Inositol Pyrophosphates, Science, 316, 109-112 (2007). PubMed Full Text

N. Maheshri & E.K. O’Shea, Living with Noisy Genes: How Cells Function Reliably with Inherent Variability in Gene Expression, Annual Review of Biophysics and Biomolecular Structure, 36:413-34 (2007). pdf

A. Belle, E.K. O'Shea, et al, Quantification of protein half-lives in budding yeast proteome, Proc. Natl. Acad. Sci USA, 103, 13004-13009 (2006). PubMed pdf data 1 data 2

A. Bar-Even, J. Paulsson, N. Maheshri, M. Carmi, E. O'Shea, Y. Pilpel, & N. Barkai, Noise in protein expression scales with natural protein abundance, Nature Genetics, 38, 636-643 (2006). PubMed

N. J. Krogan et al., Global Landscape of Protein Complexes in the Yeast Saccharomyces cerevisiae, Nature, 440, 637-643 (2006). PubMed

N. Dephoure, R. Howson, J. Blethrow, K. M. Shokat & E.K. O'Shea, Combining Chemical Genetics and Proteomics to Identify Protein Kinase Substrates, Proc. Natl. Acad. Sci USA 102, 17940-17945 (2005). PubMed pdf

J.M. Raser & E.K. O'Shea, Noise in Gene Expression: Origins, Consequences, and Control, Science 309, 2010-2013 (2005). PubMed Abstract Full text

M.R. Thomas & E.K. O'Shea, An Intracellular Phosphate Buffer Filters Fluctuations in Extracellular Phosphate Levels, Proc. Natl. Acad. Sci USA 102, 9565-9570 (2005). PubMed pdf

R. Howson, W.-K. Huh, S. Ghaemmaghami, J.V. Falvo, K. Bower, A. Belle, N. Dephoure, D.D. Wykoff, J.S. Weissman & E.K. O'Shea, Construction, Verification, and Experimental Use of Two Epitope-Tagged Collections of Budding Yeast Strains, Comp. Funct. Genomics 6, 2-16 (2005). pdf

S. Huang & E.K. O'Shea, A Systematic High-Throughput Screen of a Yeast Deletion Collection for Mutants Defective in PHO5 Regulation, Genetics 169, 1859-1871 (2005). PubMed pdf

D.D. Wykoff & E.K. O'Shea, Identification of Sumoylated Proteins by Systematic Immunoprecipitation of the Budding Yeast Proteome, Mol. Cell. Proteomics 4, 73-83 (2005). PubMed pdf

J.S. Weissman & E.K. O'Shea, 2004 Irving Sigal Young Investigator Award, Protein Sci. 13, 3333-3335 (2004). PubMed pdf

R.M. Marion, A. Regev, E. Segal, Y. Barash, D. Koller, N. Friedman & E.K. O'Shea, Sfp1 is a Stress- and Nutrient-Sensitive Regulator of Ribosomal Protein Gene Expression, Proc. Natl. Acad. Sci USA 101, 14315-14322 (2004). PubMed

J.M. Raser & E.K. O'Shea, Control of Stochasticity in Eukaryotic Gene Expression, Science, 304, 1811-1814 (2004). PubMed pdf suppl

D.J. Steger & E.K. O'Shea, Genetic Analysis of Chromatin Remodeling Using Budding Yeast as a Model, Methods Enzymol., 377, 55-60 (2004). PubMed pdf

M. Byrne, N. Miller, M. Springer & E.K. O'Shea, A Distal, High-affinity Binding Site on the Cyclin-CDK Substrate Pho4 Is Important for Its Phosphorylation and Regulation, J. Mol. Biol., 335, 57-70 (2004). PubMed pdf

M. Springer*, D.D. Wykoff*, N. Miller & E.K. O'Shea, Partially Phosphorylated Pho4 Activates Transcription of a Subset of Phosphate-Responsive Genes, PLoS Biol., 1, 261-270 (2003). PubMed

W.-K. Huh*, J.V. Falvo*, L.C. Gerke, A.S. Carroll, R.W. Howson, J.S. Weissman & E.K. O'Shea, Global Analysis of Protein Localization in Budding Yeast, Nature, 425, 686-691 (2003). PubMed pdf

S. Ghaemmaghami, W.-K. Huh, K. Bower, R.W. Howson, A. Belle, N. Dephoure, E.K. O'Shea & J.S. Weissman, Global Analysis of Protein Expression in Yeast, Nature, 425, 737-741 (2003). PubMed pdf

D.J. Steger, E.S. Haswell, A. Miller, S. Wente & E.K. O'Shea, Regulation of Chromatin Remodeling by Inositol Polyphosphates, Science, 299, 114-116 (2003). PubMed pdf suppl

A.S. Carroll & E.K. O’Shea, Pho85 and Signaling Environmental Stress, Trends Biochem. Sci., 27, 87-93 (2002). PubMed pdf

S.M. O'Rourke, I. Herskowitz & E.K. O'Shea, Yeast Go Whole HOG for the Hyperosmotic Response, Trends in Genetics, 18, 405-412 (2002). PubMed pdf

D.D. Wykoff & E.K. O'Shea, Phosphate transport and sensing in
Saccharomyces cerevisiae, Genetics, 159, 1491-1499 (2002). PubMed

A.S. Carroll, A.C. Bishop, J.L. DeRisi, K. Shokat & E.K. O’Shea, Chemical Inhibition of the Pho85 Cyclin-Dependent Kinase Reveals an Expanded Role in the Environmental Stress Response, Proc. Natl. Acad. Sci. USA 98,12578-12583 (2001). PubMed

A. Komeili & E.K. O'Shea, New Perspectives on Nuclear Transport, Ann. Rev. Genetics, 35, 341-364 (2001). PubMed

S. Huang, D. Jeffery, M. Anthony & E.K. O'Shea, Functional Analysis of the Cyclin-Dependent Kinase Inhibitor Pho81 Identifies a Novel Inhibitory Domain, Mol. Cell. Biol.21, 6695-6705 (2001). PubMed

D.A. Jeffery, M. Springer, D. King & E.K. O'Shea, Multi-Site Phosphorylation of Pho4 by the Cyclin-CDK Complex Pho80-Pho85 is Semi-Processive with Site Preference, J Mol. Biol. 306, 997-1010 (2001). PubMed :: Supplemental Materials

M.E. Lenburg & E.K. O'Shea, Genetic Evidence for a Morphogenetic Function of the Saccharomyces cerevisiae Pho85 Cyclin-Dependent Kinase, Genetics 157, 39-51 (2001). PubMed

E.K. O'Shea & I. Herskowitz, The Ins and Outs of Cell Polarity, Nature Cell Biol. 2, E39-E41 (2000). PubMed

W.-T. Lau, R.W. Howson, P. Malkus, R. Schekman & E.K. O'Shea, Pho86p, an ER Resident Protein in Saccharomyces cerevisiae, is Required for ER Exit of the High Affinity Phosphate Transporter Pho84p, Proc. Natl. Acad. Sci. USA 97, 1107-1112 (2000). PubMed

A. Komeili & E.K. O'Shea, Nuclear Transport and Transcription, Curr. Opin. Cell Biology 12, 355-360 (2000). PubMed

A. Komeili, K.P. Wedaman, E.K. O'Shea & T. Powers, Mechanism of Metabolic Control: TOR Signaling Links Nitrogen Quality to the Activity of the Rtg1p and Rtg3p Transcription Factors, J.Cell Biology 151, 863-878 (2000). PubMed

E.S. Haswell & E.K. O’Shea, An In Vitro System Recapitulates Chromatin Remodeling at the S. cerevisiae PHO5 Promoter, Mol. Cell. Biol.19, 2817-2827 (1999). PubMed

A. Komeili & E.K. O'Shea, Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4, Science 284, 977-980 (1999). PubMed

A. Kaffman & E.K. O'Shea, Regulation of Nuclear Localization: A Key to a Door, Ann. Rev. Cell Biol. 15, 291-339 (1999). PubMed

A. Kaffman, N.M. Rank & E.K. O’Shea, Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121, Genes & Dev., 12, 2673-2683 (1998). PubMed

A. Kaffman, N.M. Rank, E.M. O’Neill, L. Huang & E.K. O’Shea, The Receptor Msn5 Exports the Phosphorylated Transcription Factor Pho4 Out of the Nucleus, Nature 396, 482-486 (1998). PubMed

W.-T. Lau, K.R. Schneider & E.K. O’Shea, A genetic study of signaling processes for repression of PHO5 transcription in S. cerevisiae, Genetics 150, 1349-1359 (1998). PubMed

E.S. Haswell & E.K. O’Shea, Specificity and Targeting of ATP-Dependent Chromatin Remodeling Machines in Yeast", Cold Spring Harbor Symposium on Quantitative Biology 63, 563-567 (1998). PubMed

E.M. O'Neill, A. Kaffman, E.R. Jolly & E.K. O'Shea, Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex, Science, 271, 209-212 (1996). PubMed

M.E. Lenburg & E.K. O'Shea, Signaling Phosphate Starvation, TIBS 10, 383-387(1996). PubMed

E.M. O'Neill & E.K. O'Shea, Cyclins in initiation, Nature 374, 121-122 (1995). PubMed

A. Kaffman, I. Herskowitz, R. Tjian & E.K. O'Shea, Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85, Science 263, 1153-1156 (1994). PubMed

K.R. Schneider, R.L. Smith & E.K. O'Shea, Phosphate-Regulated Inactivation of the PHO80-PHO85 Kinase by the CDK Inhibitor PHO81, Science 266, 122-126 (1994). PubMed

E.K. O'Shea, K.J. Lumb & P.S. Kim, Peptide Velcro: Design of a Heterodimeric Coiled Coil, Current Biology 3, 658-667 (1993). PubMed

E.K. O'Shea, R. Rutkowski & P.S. Kim, Mechanism of Specificity in the Fos/Jun Oncoprotein Heterodimer, Cell 68, 699-708 (1992). PubMed

R. Rasmussen, D. Benvegnu, E.K. O'Shea, P.S. Kim & T. Alber, X-ray Scattering Indicates that the Leucine Zipper is a Parallel Coiled Coil, Proc. Natl. Acad. Sci. USA 88, 561-564 (1991). PubMed

E.K. O'Shea, J.D. Klemm, P.S. Kim & T. Alber, X-ray Structure of the GCN4 Leucine Zipper, A Two-Stranded, Parallel Coiled Coil, Science 254, 539-544 (1991). PubMed

T.G. Oas, L.P. McIntosh, E.K. O'Shea, F.W. Dahlquist & P.S. Kim, Secondary Structure of a Leucine Zipper Determined by Nuclear Magnetic Resonance Spectroscopy, Biochemistry 29, 2891-2894 (1990). PubMed

J.H. Hu, E.K. O'Shea, P.S. Kim & R.T. Sauer, Sequence Requirements for Coiled-Coils: Analysis With Lambda Repressor-GCN4 Leucine Zipper Fusions, Science 250, 1400-1403 (1990). PubMed

E.K. O'Shea, R. Rutkowski & P.S. Kim, Evidence that the Leucine Zipper is a Coiled Coil, Science 243, 538-542 (1989). PubMed

E.K. O'Shea, R. Rutkowski, W.F. Stafford, III & P.S. Kim, Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun, Science 245, 646-648 (1989). PubMed

 

 

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