Under nutrient limitation cells have a common response irregardless of the limiting nutrient which involves upregulation of stress response genes, downregulation of the translational machinary and a switch in their metabolism. While many nutrient specific responses have been intensely investigated I am interested in how the cell integrates various nutrient signals into this concerted output. I am currently investigating whether the cyclin-dependent kinase inhibitor, Pho81, an upstream regulator of the phosphate signaling pathway, may signal to other nutrient sensing pathways.
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