O'Shea Lab > People > Young-Sam Lee
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| Regulation of Pho80/Pho85
cyclin-CDK complex by nutrients and
their metabolites |
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| I am interested in the mechanism connecting
environmental changes to Pho85 CDK activity. Pho85 is a kinase involved in several
environment responses - most notably that of phosphate response (PHO) systems.
Phosphate starved cells inactivate Pho85 kinase activity leading
to the dephosphorylation of Pho4 transcription factor and expression of phosphate
response genes. Using biochemical and proteomics tools, I am investigating
the mechanism connecting phosphate availability and the kinase
activity. I am also interested in the dynamics of nutrients and other
small molecules in cells and their effects on protein/gene functions.
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