In order to respond to their changing environment,
cells must convert extracellular stimuli into
a concerted cellular response. In yeast, the
high osmolarity glycerol (HOG) pathway controls
the cellular response to osmotic stress through
a complex network of gene expression and repression.
This complex network requires the concerted action
of transcription factors, transcriptional machinery,
and chromatin remodeling complexes. I plan to
investigate additional factors that control gene
expression under osmotic stress conditions such
as global positioning of nucleosomes and rearrangement
of histone modifications using high throughput
sequencing technology.
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