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O'Shea Lab > People > Harold Kim

Quantitative characterization of a network module in PHO signaling pathway
Harold Kim <hdkim@mcb>
In order to understand how homeostatic properties of the PHO (phosphate responsive signaling) network as a whole come about, it is necessary to characterize each signaling unit that composes the network. The transcription factor, Pho4, is at the hub of the PHO pathway. According to the extent of its phosphorylation, it regulates the expression of other proteins in the PHO network, such as Pho84 and Pho5. I am interested in measuring the promoter activities of PHO84 and PHO5 as a function of various input levels of Pho4 from single cells, both in steady state and in pre-steady state. In particular, we are trying to understand the mechanism of high cooperativity or sensitivity of the promoter response in light of chromatin remodeling and gain insights into the significance of the measured response characteristics in the context of homeostatic behavior of a cell.


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