Recent Publications

    López, D., Vlamakis, H., Losick, R., Kolter, R. Cannibalism enhances biofilm development in Bacillus subtilis Molecular Microbiol. 74:609-618 (2009). (PDF)

    Lue, R., and Losick, R. A handbook for Hands-On Learning Science 323:40-42 (2009). (PDF)

    Ramamurthi, K. and Losick, R. Ramamurthi, K. and Losick, R. Negative membrane curvature as a cue for subcellular localization of a bacterial protein Proc. Natl. Acad. Sci. USA 106:13541-13545 (2009).  (PDF)

    Camp., A.H. and Losick, R. A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. Genes & Development 23:1014-1024 (2009). (PDF)

    Rahn-Lee, L., Gorbatyuk, B.,Skovgaard, O., Losick, R. The Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus subtilis.  J Bacteriol., 191: 3736-3739 (2009). (PDF)

    Ramamurthi, K. and Losick, R. Geometric Cue for Protein Localization in a Bacterium (2009) Science  323:1354-1357 (2009). (PDF)

    Chai, W., Kolter, R. and Losick, R. A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and its involvement in biofilm formation. Journal of Bacteriology  191: 2423-2430 (2009). (PDF)

    Lopez, D., Fischbach, M.A., Chu, F., Losick, R., and Kolter, R. Potassium Leakage Triggers Multiellularity in a Bacterium. Proc. Natl. Acad. Sci. USA 106:280–285 (2009). (PDF)

    Banse A.V., Chastanet A., Rahn-Lee L., Hobbs E.C., Losick R. Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis. 105:15547-52 Proc. Nat. Acad. Sci. USA (2008). (PDF)Kain J., He G.G., Losick R. Polar localization and compartmentalization of ClpP proteases during growth and sporulation in Bacillus subtilis. J Bacteriol. 190:6749-57 (2008). (PDF)

    Ramamurthi, K.S., and Losick R. Grasping at Origins Cell 134:916-918 (2008). (PDF)

    Kontnik R., Bosak T., Butcher R.A., Brocks J.J., Losick R., Clardy J., Pearson A. Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Org Lett. 10:3551-4 (2008). (PDF)

    Ramamurthi KS, Losick R. ATP-driven self-assembly of a morphogenetic protein in Bacillus subtilis. Molec. Cell. 31:406-14 (2008). (PDF)

    Camp, A.H., and Losick, R. A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Molecular Microbiol. 69:402-417 (2008). (PDF)

    Chu, F., Kearns, D.B., McLoon, A., Chai, Y., Kolter, R., and Losick R. A novel regulatory protein governing biofilm formation in Bacillus subtilis. Molecular Microbiol. 68:1117-1127 (2008). (PDF)

    Earl AM, Losick R, Kolter R. Ecology and genomics of Bacillus subtilis. Trends Microbiol. 16:269-75 (2008).(PDF)

    Bosak, T. Losick, R., and Pearson, A. A polycyclic terpenoid that alleviates oxidative stress. PNAS 105:6725-6729 (2008). (PDF)

    Handler, A.A., Lim, J.E., and Losick, R. Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis. Molecular Microbiol. 68:588-599 (2008). (PDF)

    Losick, R. and Desplan, C. Stochasticity and Cell Fate. Science 320:65-68 (2008). (PDF)

    Vlamakis, H., Aguilar, C., Losick, R., Kolter, R. Control of cell fate by the formation of an architecturally complex bacterial community. Genes and Development 22:945-953 (2008). (PDF)

    Chai Y, Chu F, Kolter R, Losick R. Bistability and biofilm formation in Bacillus subtilis. Molecular Microbiology (2008). (PDF)

    Aguilar C, Vlamakis H, Losick R, Kolter R. Thinking about Bacillus subtilis as a multicellular organism. Current Opinion in Microbiology 10:638-643 (2007). (PDF)

    Ferguson, C.C., Camp, A. H., Losick, R. gerT, a newly discovered germination gene under the control of the sporulation transcription   factor sK in Bacillus subtilis. J Bacteriol 189:7681-7689. (2007) Aug 24. (PDF)

    Chastanet A., Losick R. Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins. Molecular Microbiology, 64:139-152 (2007).  (PDF)

    Earl, A. , Losick, R., and Kolter, R. Bacillus subtilis Genome Diversity
    J. Bacteriol 189: 1163-1170 (2007). (PDF)

    Ramamurthi, K.S., Clapham, K.R., Losick, R. Peptide anchoring spore coat assembly to the outer forespore membrane in Bacillus subtilis. Molecular Microbiology, 62:1547-1557 (2006). (PDF)

    Bassler, B. and Losick, R. Bacterially speaking. Cell 125: 237-246 (2006). (PDF)

    Dubnau, D. and Losick, R. Bistability in bacteria. Molecular Microbiology, 61:564-572 (2006). (PDF)

    Ellermeier, C.D. and Losick, R. Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis. Genes & Development 20: (2006). (PDF)

    Wang, S.T., Setlow, B., Conlon, E.M., Lyon, J.L., Imamura, D., Sato, T., Setlow, P. Losick, R., and Eichenberger, P. The forespore line of gene expression in Bacillus subtillis. J. Molec. Biol. 358:16-37 (2006). (PDF)

    Ellermeier, C.D., Hobbs, Errett C., Gonzalez-Pastor, J.E., Losick R. A Three-Protein Signaling Pathway Governing Immunity to a Bacterial Cannibalism Toxin Cell 124:549-559 (2006). (PDF)

    Branda, S., Chu, F., Kearns, D., Losick, R., and Kolter, R. A major protein component of the Bacilllus subtilis biofilm matrix. Molecular Microbiology 59:1229-1238 (2006) (PDF).

    Silvaggi, J., Perkins, J. and Losick, R.Genes for Small, Noncoding RNAs under Sporulation Control in Bacillus subtilis. J. Bacteriol 188:532-541 (2006). (PDF)

    Chu, F., Kearns, D., Branda, S, Kolter, R., and Losick, R. Targets of the master regulator of biofilm formation in Bacillus subtilis. Molecular Microbiology 59:1216-1228 (2006). (PDF)

    Kearns, D.B. and Losick R. Cell populations heterogeneity during growth of Bacillus subtilis Genes & Development 19:3083-3094 (2005). (PDF)

    Silvaggi, J, Perkins, John B., and Losick, R. Small untranslated RNA antitioxin in Bacillus subtilis J. Bacteriol 187:6641-6650 (2005). (PDF)

    Fujita, M. and Losick, R. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes & Development 19:2236-2244 (2005). (PDF)

    Dworkin, J., and Losick, R. Developmental commitment in a Bacterium. Cell 121:401-409 (2005). (PDF)

    Carniol, K., Ben-Yehuda, S., King, N., and Losick, R. Genetic Dissection of the sporulation Protein SpoIIE and its role in asymmetric division in Bacilllus subtilis. J. Bacteriol 187:3511-3520 (2005). (PDF)

    Ramamurthi, K. S., and Losick, R.M. Protein Localization: Reach out and Touch the Forespore. Current Biology. 15:R165-R167. (2005) (PDF)

    Ben-Yehuda, S., Fujita, M., Liu, X., Gorbatyuk, B., Skoko, D., Yan J., Marko, J.F., Liu, J.S., Eichenberger, P., Rudner, D. and Losick, R. Defining a centromere-like Element in Bacillus subtilis by identifying the binding sites for the chromosome-anchoring protein RacA. Molec. Cell, 17: 773-782 (2005). (PDF)

    Fujita, M, Gonzalez-Pastor, E, and Losick, R. High- and Low-Threshold Genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 187:1357-1368 (2005). (PDF)

    Kearns, D., Chu, Frances, Branda, S., Kolter, R., and Losick R. A Master regulator for biofilm formation by Bacillus subtilis. Molec Microbiol 55:739-749 (2005). (PDF)

    Silvaggi, J., Popham, D., Driks, A., Eichenberger, P., Losick, R. Unmasking Novel Sporulation Genes in Bacillus subtilis. J. Bacteriol 186:8089-8095 (2004). (PDF)

    Eichenberger, P., Fujita, M., Jensen, S.T., Conlon, E.M., Rudner, D.Z., Wang, S.T., Ferguson, C., Haga, K., Sato, T., Liu, J.S., Losick, R. The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis. PLoS Biol. 2004 Sep 21;2(10):E328. (PDF) Companion website.

    Branda, S, Gonzalez-Pastor, J., Dervyn, E., Ehrlich, S., Losick, R., Kolter, R. Genes Involved in Formation of Structured Multicellular Communities by Bacillus subtilis. J. Bacteriol 186:3970-3979 (2004). (PDF)

    van Ooij, C., Eichenberger, P., Losick, R. Dynamic Patterns of Subcellular Protein Localization during Spore Coat Morphogenesis in Bacillus subtilis. J. Bacteriol 186:4441-4448 (2004) (PDF)

    Carniol, K., Kim T., Price, C. Losick, R. Insulation of the Sigma F Regulatory System in Bacillus subtilis J. Bacteriol 186:4390-4394 (2004). (PDF)

    Gehring, A., Wang, S., Kearns, D., Storer, N., Losick R. Novel Genes That Influence Development in Streptomyces coelicolor. J. Bacteriol 186:3570-3577 (2004). (PDF)

    Kearns, D., Chu , F., Rudner, R. and Losick, R. Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility. Molec. Microbiol 52:357-369 (2004). (PDF)

    Carniol, K., Eichenberger, P., Losick, R. A Threshold Mechanism Governing Activation of the Developmental Regulatory Protein sf in Bacillus subtilis J. Biol. Chem. 279:14860-14870 (2004). (PDF)

    Bentley, S.D.,  Brown, S., Murphy, L.D., Harris, D.E., Quail, M.A., Parkhill J., Barrell, B.G., McCormick, J.R., Santamaria, R.I., Losick, R., Yamasaki M., Kinashi, H., Chen, C.W., Chandra, G., Jakimowicz, D., Kieser, H. M., Kieser, T., and Chater, K.F. SCP1, a 356 023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolar A3(2) Molec. Microbiol. 51:1615-1628 (2004). (PDF)