Gaudet Lab Homepage

A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. 2008 May;4(5):372-9. Epub 2008 Mar 26.

Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter. Biochemistry. 2008 May 27;47(21):5699-708. Epub 2008 May 2.

TRP channels entering the structural era. J Physiol. 2008 Jun 5.

C. B. Phelps, R. J. Huang, P. V. Lishko, R. R. Wang and R. Gaudet (2008) Structural analyses of the Ankyrin Repeat Domain of TRPV6 and related TRPV ion channels. Biochemistry 47, 2476-2484.

C. B. Phelps, and R. Gaudet (2007) The Role of the N-Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization. Journal of Biological Chemistry 282, 36474-80.

P. C. Sabeti, P. Varilly, B. Fry. J. Lohmueller, E. Hostetter, C. Costapas, X. Xie, E. H. Byrne, S. A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander & The International HapMap Consortium (2007) Genome-wide detection and characterization of positive selection in human populations. Nature 449, 913-918

C. B. Phelps, E. Procko, P. V. Lishko, R. R. Wang, and R. Gaudet (2007) Insights into the Roles of Conserved and Divergent Residues in the Ankyrin Repeats of TRPV Ion Channels. Channels 1, 148-151.

P.V. Lishko, E. Procko, X. Jin, C.B. Phelps, and R. Gaudet (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54:905-918.

C. Schlieker, W.A. Weihofen, E. Frijns, L.M. Kattenhorn, R. Gaudet, and H.L. Ploegh (2007) Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell. 25(5):677-87.

E. Procko, I. Ferrin-O'Connell, S-.L. Ng, and R. Gaudet (2006) Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Mol Cell. 24(1):51-62.

X. Jin, J. Touhey, and R. Gaudet (2006) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J. Biol. Chem. 281(35):25006-10.

E. Procko, G. Raghuraman, D. C. Wiley, M. Raghavan, and R. Gaudet (2005) Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunol. Cell. Biol. 83: 475-482.

S. Misaghi, P. J. Galardy, W. J. N. Meester, H. Ovaa, H. L. Ploegh, and R. Gaudet (2005) Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J. Biol. Chem. 280:1512-1520.

S. Misaghi, Z.-Y. J. Sun, P. Stern, R. Gaudet, G. Wagner and H. Ploegh (2004) A structural and functional analysis of the human cytomegalovirus US3 protein. J. Virol. 78: 413-423.

M. Obin, B. Y. Lee, C. Thulin , G. Meinke, A. Bohm, R. H. Lee, R. Gaudet, J. A. Hopp, V. Y. Arshavsky, B. M. Willardson and A. Taylor (2002) Ubiquitylation of Transducin (T) subunits: Regulation by Phosducin. J. Biol. Chem. 277: 44566-44575.

R. Gaudet and D. C. Wiley (2001) Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 20: 4964-4972.

M. Holm, C. S. Hardtke, R. Gaudet, and X.-W. Deng (2001) Identification and characterization of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. 20: 118-127.

B. E. Gewurz, R. Gaudet, D. Tortorella, E. W. Wang and H. L. Ploegh (2001) Virus subversion of immunity: a structural perspective. Curr. Opin. Immunol . 13: 442-450.

B. E. Gewurz, R. Gaudet, D. Tortorella, E. W. Wang, H. L. Ploegh and D. C. Wiley (2001) Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc. Natl Acad. Sci. USA 98: 6794-6799.

R. Gaudet, J. R. Savage, J. N. McLaughlin, B. M. Willardson, and P. B. Sigler (1999) A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G Proteins by phosducin. Mol. Cell 3: 649-660.

A. Bohm, R. Gaudet, and P. B. Sigler (1997) Structural aspects of heterotrimeric G-protein signaling. Curr. Opin. Biotechnol. 8: 480-487.

R. Gaudet, A. Bohm, and P. B. Sigler (1996) Crystal structure at 2.4 Å resolution of the complex of transducin bg and its regulator, phosducin. Cell 87: 577-588.